Electron microscopic changes in the nasal membrane of patients with COVID-19 depending on the clinical form and the period of the disease

Given that COVID-19 is a global public health problem and almost all countries in the world have been severely affected by pandemic, research being actively pursued to better understand effects of virus on human cells. However, it not clear what changes are observed cells main gate infection – mucosa mouth nose at different clinical forms periods disease. Understanding ultra-structural cell SARS-CoV-2 targets may help clarify pathogenic aspects lower respiratory tract. In this study, elements life cycle epithelium patients with were evaluated using electron microscopy for purpose detecting peculiarities viral activity depending form period Bioptats nasal mucous membrane taken from subsequently examined microscopy. The severity structural tissue samples, presence SARSCoV-2 determined, then bioptats grouped according process (inapparent, acute upper tract infections, lung disease) It has established most characteristic first week caused occurring disease, while infections had highest density vesicles within cells, formation smooth virus-free common inapparent forms. data obtained indicate classical virus-induced (vesicles particles signs their release cell) localized (respiratory tract) cases generalized (viral lungs probably other organs systems) accumulation infectious agent high concentrations vesicles.